Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound
نویسندگان
چکیده
BACKGROUND Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before. AIM To perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas. METHODS We performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma. An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging. A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria. Results were related to histopathology. RESULTS We observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase. HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns. CONCLUSION Our study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors' biology. CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.
منابع مشابه
Intraoperative Contrast Enhanced Ultrasound Evaluates the Grade of Glioma
OBJECTIVE The aim of our study was to investigate the value of intraoperative contrast enhanced ultrasound (CEUS) for evaluating the grade of glioma and the correlation between microvessel density (MVD) and vascular endothelial growth factor (VEGF). METHODS We performed intraoperative conventional ultrasound (CUS) and CEUS on 88 patients with gliomas. All of the patients have undergone surger...
متن کاملDiagnostic Significance of Intraoperative Ultrasound Contrast in Evaluating the Resection Degree of Brain Glioma By Transmission Electron Microscopic Examination
BACKGROUND Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. In order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of brain glioma by transmission electron microscopic (TEM) examination, it is impor...
متن کاملCurrent and Future Novel Treatments for Glioblastoma Multiforme
After decades of slight to modest changes in outcomes, survival for patients with glioblastoma has shown consistent and sustained improvement. Whether this improvement is due to enhanced imaging technologies, increased diagnostic accuracy, earlier detection, advanced microsurgical techniques, functional tissue preservation, postoperative critical care, targeted radiation, or novel adjuvant ther...
متن کاملValue of dynamic, contrast-enhanced MRI & intraoperative ultrasound for management of a nonpalpable, incidental, testicular Leydig-cell tumor
We report a case of a small, intratesticular, incidentally identified, nonpalpable Leydig-cell tumor in which preoperative, dynamic, contrast-enhanced MRI was essential in characterizing the lesion as a neoplasm. Sonographic evaluation failed to demonstrate internal color Doppler flow, resulting in a differential diagnosis that included debris-filled cyst. At surgical resection, intraoperative ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2014 شماره
صفحات -
تاریخ انتشار 2014